Presentations > A 2-D imaging dosimeter for photodynamic therapy

A 2-D imaging dosimeter for photodynamic therapy




Photodynamic Therapy (PDT) is a promising modality for cancer treatment. Typically, a laser is used to photo-excite a photosensitizer (PS) that subsequently collides with oxygen molecules promoting them to the metastable singlet delta state O2. Singlet oxygen molecules are believed to be the species that destroys cancerous cells during PDT. In this paper we describe a novel 2D imaging sensor for photosensitizer fluorescence and singlet oxygen luminescence. We describe our instrument and initial results from both in-vitro and in-vivo studies that indicate that this system may be a valuable dosimeter for both PDT researchers and eventually for clinical application.

Copyright © 2019 Society of Photo-Optical Instrumentation Engineers. Presented at SPIE Photonics West 2019, SPIE Paper No. 10860-23, 2-7 February, 2019. This paper is made available as an electronic reprint (preprint) with permission of SPIE. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.