Intraoperative Fluorescence Nerve Imager
PSI has developed an intraoperative fluorescence imager that is capable of identifying nerve tissue in the surgical bed. The PSI fluorescence imager uses an innovative tempo-spatial modulation technique to reject the ambient light background, eliminating the need for turning off the surgical lighting during fluorescence image acquisition. This significantly reduces the interruption to the normal surgical workflow, lowering the barrier for clinical adoption.
Key Features
- Strong light background suppression using advanced Tempo-Spatially Modulated (TSM) illumination technology.
- Novel optical design for simultaneous, multiple-wavelength fluorescence imaging.
- Strong suppression of operating room light background by a factor of >16,000.
Figure 1. Mechanical design (A and B) and photographs of fabricated Gen-II TSM fluorescence imager. Figure 2. Line-scan (i.e. modulated and demodulated fluorescence) and wide-field (i.e. visible RGB) images of sciatic nerve and blood vessels from an in vivo mouse. The fluorescence images were obtained by the excitations of 637 nm and 785 nm lasers. Scale bar = 0.5 cm.
