Products > Bio Pharma > Singlet Oxygen Dosimeter

Singlet Oxygen Dosimeter

Real-time singlet oxygen detection

Enables real-time measurement of singlet oxygen produced during photodynamic therapy (PDT) and UV irradiation of human skin

The PSI singlet oxygen dosimeter is based on an innovative computational spectroscopy approach to achieve highly sensitive luminescence spectral measurements using a high-quantum efficiency signal-point detector and a spatial light modulator. The high signal-to-noise-ratio (SNR) spectroscopic data provided by the dosimeter enables accurate determination of photosensitizer (PS) luminescence baseline via spectral fitting and extraction of the singlet oxygen phosphorescence signal based solely on spectroscopic decomposition, without the need for temporal gating. This enables direct measurement of singlet oxygen production during continuous-wave PDT treatment, critical for clinical use as a real-time dosimeter.

Key Features

  • Non-invasive optical detection
  • CW detection
  • High detection sensitivity
  • Fiber-coupled signal collection
  • Imaging guidance for alignment

Specifications:

  • Spectral resolution: < 10 nm
  • Single measurement time: < 8 s
  • Light collector working distance: ~ 100 mm

Alpha prototype and typical measurement of luminescence spectra from a PBD solution in methanol

Benefit to Customer

Enables singlet oxygen dosimetry during PDT treatment and during UV skin irradiation to support studies of the carcinogenesis effect of UV exposure.

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