Products > Pharma and Medical Sensors > LyoFlux

LyoFlux™

Process Analytical Technology (PAT)

Key Features

LyoFlux™

Real-Time, Non-Intrusive Monitoring of Pharmaceutical Lyophilization

The TDLAS-based LyoFlux™ sensor provides batch average, real-time measurements of the water vapor flow rate between the lyophilizer drying chamber and the condenser. Measurements linked to a heat and mass transfer model of lyophilization enable determination of key process parameters, including product temperature (Tb & Tp), vial heat transfer (Kv) and product resistance to drying (Rp) coefficients and dry layer thickness. Supports QbD cycle development.

  •  Instantaneous mass flow and integrated water removed measurements
  •  Primary & secondary drying endpoint determinations
  •  Efficient determination of vial heat transfer, Kv, and product resistance to drying, Rp coefficients
  •  Efficient determination of lyophilizer equipment capability curve (choked flow determination vs pressure)
  •  Enables efficient QbD process design development
  •  24/7 unattended operation
  •  Direct communication with lyophilizer;
  •  Enables automated process development and control

Enables lyophilization cycle monitoring, development and process control

Instrument Brochure
LyoFlux™ Sensor Control Unit and Optical Spool measurement head

Benefit to Customer

Enables lyophilization cycle monitoring, development and process control

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