LyoFlux™

The TDLAS-based LyoFlux™ sensor provides batch average, real-time measurements of the water vapor flow rate between the lyophilizer drying chamber and the condenser. Measurements linked to a heat and mass transfer model of lyophilization enable determination of key process parameters, including product temperature (Tb & Tp), vial heat transfer (Kv) and product resistance to drying (Rp) coefficients and dry layer thickness. Supports QbD cycle development.

•  Instantaneous mass flow and integrated water removed measurements
•  Primary & secondary drying endpoint determinations
•  Efficient determination of vial heat transfer, Kv, and product resistance to drying, Rp coefficients
•  Efficient determination of lyophilizer equipment capability curve (choked flow determination vs pressure)
•  Enables efficient QbD process design development
•  24/7 unattended operation
•  Direct communication with lyophilizer;
•  Enables automated process development and control

Enables lyophilization cycle monitoring, development and process control