Products > Bio Pharma > Microwave Freeze-Drying

Pharmaceutical Lyophilization

Next Generation Pharmaceutical Manufacturing

Microwave Assisted pharmaceutical Freeze-Drying (MAFD)

PSI, in collaboration with UConn, is developing databases and models to support the development of next generation microwave assisted pharmaceutical lyophilization. Under support from the FDA, PSI is measuring fundamental microwave absorption properties of example pharmaceutical product formulations that will be combined with heat and mass transfer models of lyophilization to enable industry to develop dedicated microwave assisted dryers and processes appropriate for regulated pharmaceutical products.

Key Features

Pharmaceutical formulation microwave loss constants as a function of frequency and temperature
Custom heat and mass transfer models to guide process development
Data and models provide fundamental underpinning to support next-generation pharmaceutical lyophilization

Theory of µwave power absorption and ice sublimation at 2.45 GHz.

Benefit to Customer

Fundament knowledge of µwave loss constants and a µwave heating and mass transfer model of freeze drying will enable QbD based development of drying systems and processes