Publications & Presentations

Automated analysis of tissue heterogeneity based on OCT images for improving personalized cancer therapy effectiveness

Mark Scimone, Gopi Maguluri, Jesung Park, Nicusor Iftimia
SPIE, Photonics West,
San Francisco, CA, February 4, 2020

Optical coherence tomography enables high-resolution, nondestructive imaging up to 1 mm in depth.

• Full 3D reconstructions allow for visualization of the full extent of tumor

• Estimation of tumor content allows for spatial exclusion in important personalized cancer treatment assays.
– Also useful for relevant 3D drug development assays

A High Throughput Spectroscopic Dosimeter for Simultaneous Measurement of Singlet Oxygen and Photosensitizer during PDT Treatment

Y. Zhao, T. Moritz, M. Hinds, J. Gunn, B. W. Pogue, and S. J. Davis
SPIE Photonics West / BIOS Conference
San Francisco, CA
February 1, 2020
SPIE Paper No. 11220-7

Successful development of a singlet oxygen spectrometer applicable for PDT treatment using a cw laser

Preliminary demonstration during in vivo animal experiments

Continued animal study is ongoing.

Next step will be to reduce the system cost and potentially include time gated measurement capability.

High Yield and Economical Production of Rare Earth Elements from Coal Ash

Dorin V. Preda, Prakash B. Joshi, David P. Gamliel, Jeffrey Y. Yee, Russell D. Lambert, James C. Hower, John G. Groppo, Jr., Todd Beers, and Mike Schrock
2019 International Pittsburgh Coal Conference
Pittsburgh, PA
September 3-6, 2019

Rare Earth Elements (REE) in fossil fuel derived solids and liquids

Sensor Applications for DFB-ICLs and QCLs

Mickey B. Frish
LC Workshop
October 28, 2019
Princeton University, Princeton, NJ

We have demonstrated laboratory feasibility of novel miniature sensor packaging, with integrated laser source, sensor element, and detector on a simple monolithic platforms

Synchronized, concurrent optical coherence tomography and videostroboscopy for monitoring vocal fold morphology and kinematics

Synchronized, concurrent optical coherence tomography and videostroboscopy for monitoring vocal fold morphology and kinematics
GOPI MAGULURI, DARYUSH MEHTA, JAMES KOBLER, JESUNG, PARK, AND NICUSOR IFTIMIA
Biomedical Optics Express Vol. 10, Issue 9, pp. 4450-4461 (2019) • https://doi.org/10.1364/BOE.10.004450

Voice disorders affect a large number of adults in the United States, and their clinical evaluation heavily relies on laryngeal videostroboscopy, which captures the mediallateral and anterior-posterior motion of the vocal folds using stroboscopic sampling.

However, videostroboscopy does not provide direct visualization of the superior-inferior movement of the vocal folds, which yields important clinical insight. In this paper, we present a novel technology that complements videostroboscopic findings by adding the ability to image the coronal plane and visualize the superior-inferior movement of the vocal folds. The technology is based on optical coherence tomography, which is combined with videostroboscopy within the same endoscopic probe to provide spatially and temporally co-registered images of the mucosal wave motion, as well as vocal folds subsurface morphology. We demonstrate the capability of the rigid endoscopic probe, in a benchtop setting, to characterize the complex movement and subsurface structure of the aerodynamically driven excised larynx models within the 50 to 200 Hz phonation range. Our preliminary results encourage future development of this technology with the goal of its use for in vivo laryngeal imaging.