Real-time assessment of tissue morphology and function is a pressing clinical need. We present a low cost OCT probe based on combined position sensor feedback, as well as a data processing algorithm that enables real-time display of tissue morphology and birefringence. The preliminary evaluation of this instrument on various biological specimens has demonstrated its capability for real-time diagnosis. Its preclinical assessment in vivo on animal models of cancer was performed at MD Anderson Cancer Center. Reliable assessment of tissue morphology and birefringence has been successfully demonstrated.
© 2023 Physical Sciences Inc. All rights reserved. SPIE Paper PC12373-14. Acknowledgement Funding: NIH/NCI: 75N91019C00010, NIH/NHLBI: 1 R43 HL150948-01