Fiber-based hand-held RCM-OCT probe for noninvasive assessment of skin lesions and therapy guidance
Gopi Maguluri, John Grimble, Mircea Mujat, Jesung Park, Aliana Caron, Nicusor Iftimia
Translational Biophotonics 2022, 4( 3), e202200002. https://doi.org/10.1002/tbio.202200002
Noninvasive assessment of skin lesions, especially of basal cell carcinoma (BCC), has benefited more recently from the use of optical imaging techniques such as optical coherence tomography (OCT) and reflectance confocal microscopy (RCM).
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While RCM provides submicron scale resolution and thus enables identification of skin morphological changes of the skin, with the downside of limited penetration depth, OCT imaging of the same lesion brings the benefit of better resolving its depth of invasion. OCT and RCM can be used either individually or combined within the same instrument for the noninvasive diagnosis of nonmelanoma skin cancers (NMSCs). Their combined use has shown to provide certain benefits such as better characterization of the lesion's margins, both in depth and laterally, as well as improved sensitivity and specificity, as previously demonstrated by our team. In this article we report a new “fiber-based” implementation of the second-generation RCM-OCT hand-held probe. The fiber-based implementation of both imaging modalities enabled the construction of a smaller footprint/lower weight hand-held probe. Its preliminary evaluation on the skin of healthy volunteers is reported here, demonstrating improved capabilities for resolving sub-cellular structures and image skin morphology with micron-scale resolution to a higher depth than in the previous implementation, while also enabling the construction of angiography maps showing vascular remodeling.
Dual-mode endoscopic probe combining OCT and autofluorescence imaging for inner ear hearing loss diagnosis and therapy guidance
Jesung Park, Jeffrey Cheng, Daniel Lee, Jeffrey Holt, Hannah Goldberg, Gopi Maguluri, John Grimble, and Nicusor Iftimia
SPIE Photonics West/BIOS 2020
San Francisco, CA
February 1, 2020
Proof of Concept study has demonstrated that the combined OCT/AF imaging approach can detect morphological and biochemical changes related to inner ear SNHL.
OCT/AF technology could be used to diagnose potential causes of SNHL and evaluate the success of the hair cell regeneration therapy approaches.
Multimodal imaging microscope for intraoperative detection of breast tumor positive margins
Mark Scimone, Dorin Preda, Sharon Song, Gopi Maguluri, Savitri Krishnamurthy, Jesung Park, John Grimble ,Nicusor Iftimia
SPIE Photonics West
San Francisco, CA
February 1, 2020
Enhanced contrast fluorescence imaging was very useful in highlighting suspicious cancer presence - reduces the amount of time needed for analyzing the specimen with higher resolution microscopy, which can be applied only on the highlighted areas
Automated analysis of tissue heterogeneity based on OCT images for improving personalized cancer therapy effectiveness
Mark Scimone, Gopi Maguluri, Jesung Park, Nicusor Iftimia
SPIE, Photonics West,
San Francisco, CA, February 4, 2020
Optical coherence tomography enables high-resolution, nondestructive imaging up to 1 mm in depth.
• Full 3D reconstructions allow for visualization of the full extent of tumor
• Estimation of tumor content allows for spatial exclusion in important personalized cancer treatment assays.
– Also useful for relevant 3D drug development assays
A High Throughput Spectroscopic Dosimeter for Simultaneous Measurement of Singlet Oxygen and Photosensitizer during PDT Treatment
Y. Zhao, T. Moritz, M. Hinds, J. Gunn, B. W. Pogue, and S. J. Davis
SPIE Photonics West / BIOS Conference
San Francisco, CA
February 1, 2020
SPIE Paper No. 11220-7
Successful development of a singlet oxygen spectrometer applicable for PDT treatment using a cw laser
Preliminary demonstration during in vivo animal experiments
Continued animal study is ongoing.
Next step will be to reduce the system cost and potentially include time gated measurement capability.
High Yield and Economical Production of Rare Earth Elements from Coal Ash
Dorin V. Preda, Prakash B. Joshi, David P. Gamliel, Jeffrey Y. Yee, Russell D. Lambert, James C. Hower, John G. Groppo, Jr., Todd Beers, and Mike Schrock
2019 International Pittsburgh Coal Conference
Pittsburgh, PA
September 3-6, 2019
Rare Earth Elements (REE) in fossil fuel derived solids and liquids
