Publications & Presentations

Methods: That system was based upon an ellipsoidal optical scanning/imaging design that produces near-normal incidence scans over large patches of the eye’s surface for efficient profiling and corneal/scleral surface stitching. This method permits simultaneous imaging of pairs of ocular surfaces with respect to the scan pivot point (the system pupil), by integration of dual-conjugate optics. Coordinated dual-reference arms enable ranging to these two focal surfaces at precisely known locations with respect to the scan pivot, and to each other, on a single SDOCT spectrometer without imposing extreme requirements on the axial imaging range. Direct imaging of the eye through the reflective scan optics allows the system pupil/pivot location to be precisely positioned by the operator, while the eye’s position and orientation are monitored by a camera and controlled by a fixation display.
Results: The method has been initially demonstrated with a single imaging system by changing the beam focus and the scanning pivoting point and measuring various eye surfaces sequentially. Typical results for large area scans of cornea, iris and top of lens, and retina are shown in Fig. 1.
Conclusions: Our preliminary corneal/scleral, lenticular and retinal imaging demonstrations (performed at safe light levels for retinal imaging under NEIRB human subjects protocols) have shown coordinated optical delays and focal conjugate zoom control produce high quality SDOCT images ranging throughout the whole eye. Simultaneous measurement of anterior and posterior ocular anatomic structures and surfaces, and their precise spatial relationship to each other over wide angles, is feasible with a two-channel, dual-conjugate non-contact optical ocular biometry system in the optically accessible regions of the eye.

Tradeoff options among optical path length, absorption linestrength, linewidth, cross-interferences, and sampling methodology enable sensor designers to optimize detection for specific applications. Emerging applications are demanding increasing numbers of distributed miniaturized sensors at diminishing costs. In these applications, the TDLAS specificity is a key attribute, and its high sensitivity enables novel sampling package designs with short optical pathlengths. This paper describes a miniature hermetically-sealed backscatter TDLAS transceiver package designed for high-volume production at acceptable cost. Occupying a volume less than 1in3 and weighing less than 0.06 lb, the transceiver is a key component of TDLAS sensors intended for in-situ measurements of potentially explosive gas mixtures.

While RCM imaging detects BCC presence (diagnoses) and its lateral spreading (margins) with measured resolution of ∼1 μm, OCT imaging delineates BCC depth spreading (margins) with resolution of ∼7 μm. When delineating margins in 20 specimens of superficial and nodular BCCs, depth could be reliably determined down to ∼600 μm, and agreement with histology was within about
50 μm.