Publications & Presentations | PSI - Physical Sciences Inc.

Guiding skin cancer therapy with combined Confocal-OCT imaging

Nicusor Iftimia, Aditi Sahu, Miguel Cordova, Larissa Pastore, Gopi Maguluri, John Grimble, Mircea Mujat, Aliana Caron, Milind Rajadhyaksha, Chih-Shan Jason Chen, Christopher Barker
SPIE BIOS, 28 January - 2 February 2023, San Francisco, California, Paper # PC12368-11

In this paper we report the use of a novel multimodal imaging hand-held probe for guiding laser and radiotherapy on nonmelanoma skin cancers (NMSCs) patients.

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This probe combines the capability of reflectance confocal microscopy (RCM) with that of Optical Coherence Tomography (OCT) to reliably detect cancer markers and measure cancer depth of invasion. These capabilities have shown to be very effective in accurately measuring cancer margins and guiding the therapy.

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© 2023 Physical Sciences Inc. All rights reserved. SPIE Paper PC12368-11.
Acknowledge Funding: DoD: W81XWH11 C 0486, NIH/NCI: R44 CA117218; R44CA240040

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Laser Sensors for Monitoring, Locating, Imaging, and Quantifying Methane Emissions

Nick Aubut, Mickey Frish and Shin-Juh Chen, Paul Wehnert, Sean Epps, and Milton Heath III
Laser Sensors for Monitoring, Locating, Imaging, and Quantifying Methane Emissions
METHANE STRATEGIES FORUM 2022, June 20-22, Houston, Texas

Technological advances make it easier and less expensive to capture carbon and detect leaks from improperly capped wells, pipelines and even aging gas infrastructure in cities. The ability to measure carbon dioxide and methane is a big deal because more can be captured, used, re-injected and sequestered. Lasers are now also the key to inexpensive leak detection for natural gas

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Backscatter-TDLAS Detectors for Monitoring, Locating, Imaging, and Quantifying Methane Emissions

Mickey B. Frish, Shin-Juh Chen, Nicholas F. Aubut, and Richard T. Wainner, Paul Wehnert, Kevin Bendele and Steve Chancey
CLEO Conference, May 15-19, 2022, San Jose, California

The urgency to reduce methane emissions to the atmosphere is driving industry adoption of advanced technologies for methane measurement and monitoring. We present a suite of laser-based sensors for detecting, locating, and measuring methane sources.

© 2022 Physical Sciences Inc. All Rights reserved. Acknowledgements: Department of Energy (DoE), Advanced Project Research Agency-Energy (ARPA-E), National Institute of Occupational Health & Safety (NIOSH), Department of Transportation (DoT), Leak Survey Inc., New Era Technologies, NYSEARCH, Southern California Gas (SoCalGas), GTI Energy, Heath Consultants Inc., Physical Sciences Inc. (PSI)

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Cable Resistance in Spacecraft Deployable Mechanisms

Brian W. Schweinhart, Ziv A. Arzt, Brendan E. Nunan, Alex J. Mednick
2022 AIAA SciTech Forum, 3-7 January 2022, San Diego, CA
Paper https://doi.org/10.2514/6.2022-1623

The resistive torques of cable harnesses and service loops comprise a significant portion of the force budgets of deployable space mechanisms. The space engineering community lacks a reliable and methodical way to predict these forces early in the mechanism design process. Incumbent methods rely on estimates from heritage applications or use deployment prototype tooling.

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The latter approach is typically specific to the application and the design and therefore incurs timely and expensive iterations. This paper describes a methodology for directly predicting cable drag and resistive torque from the cable specification and deployment geometry alone. The method outlines a standard procedure for characterizing the elastoplastic and viscoelastic material properties of space cables. These experimentally-determined material properties are supplied along with deployed cable geometry to a FEA model, which predicts the cable resistive forces in a representative deployment system.

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Copyright © 2022 Physical Sciences Inc. Paper https://doi.org/10.2514/6.2022-1623 Published by the American Institute of Aeronautics and Astronautics by permission. For permission to copy or republish, contact the American Institute of Aeronautics and Astronautics 1801 Alexander Bell Drive, Suite 500, Reston, VA 20191-4344.

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An ultra-compact shortwave infrared hyperspectral imaging system

Jay Giblin, Rusha Chatterjee, Michael Chase, Michael Ascenzi, Jonathan Rameau, Julia Dupuis, Jacob A. Martin, and Joseph Meola
SPIE Defense + Commercial Sensing, 4-7 April, 2022, Orlando, FL

Physical Sciences Inc. has developed an ultra-compact shortwave infrared (SWIR) staring mode hyperspectral imaging (HSI) sensor with an additional visible full motion video (FMV) capability.

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The innovative HSI design implements a programmable micro-electromechanical system entrance slit that breaks the interdependence between vehicle speed, frame rate, and spatial resolution of conventional push-broom systems and enables staring-mode operation without cooperative motion of the host vehicle or aircraft. The FMV and HSI components fit within 1000 cm³, weigh a total of 2.1 lbs., and draw 15 W of power. The sensor mechanical design is compatible with gimbal-based deployment allowing for easy integration into ground vehicles or aircrafts. The FMV is capable of achieving NIRS-6 imagery over a 6°×6° field-of-view (FOV) at a 1500 ft. standoff. The SWIR HSI covers a spectral range of 900-1605 nm with a 15 nm spectral resolution, and interrogates a 5°×5° FOV per 1.6 s with a 2.18 mrad instantaneous FOV (1 m ground sample distance at 1500 ft.). A series of outdoor tests at standoffs up to 300 ft. have been conducted that demonstrate the payload’s capability to acquire HSI information. The payload has direct utility towards diverse remote sensing applications such as vegetation monitoring, geological mapping, surveillance, etc. The data product utility is demonstrated through the spectral identification of materials (e.g. foam and cloth) placed in the sensor’s FOV.

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Copyright © 2022 Society of Photo-Optical Instrumentation Engineers. This paper was presented at the SPIE Defense + Commercial Sensing, 4-7 April, 2022, Orlando, FL (Paper No. 12094-7), and is made available as an electronic reprint (preprint) with permission of SPIE. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

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One Dimensional Convolutional Neural Networks for Spectral Analysis

Michael S. Primrose, Jay Giblin, Christian Smith, Martin R. Anguita, Gabriel H. Weedon
SPIE Defense + Commercial Sensing, 4-7 April, 2022, Orlando, FL

A platform for building sensor specific machine learning detection algorithms has been developed to classify spectroscopic data. The algorithms are focused on long wave infrared reflectance (LWIR) and Raman spectroscopies. The classification algorithm is based on a one dimensional (1D) convolutional neural network (CNN) architecture.

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Training data is generated using an appropriate signal model that is combined with sensor specific characteristics such as spectral range, spectral resolution, and noise.
Within this paper, the performance of trained CNNs for both LWIR and Raman sensor systems has been evaluated. The evaluation uses both real and synthetic data to benchmark the performance in terms of the discriminant signal. The evaluation data consists of various chemical representations and varied noise levels. The performance of the 1D CNN approach has demonstrated high classification accuracies on data with low discriminant signals. Specifically, the CNNs have demonstrated a classification accuracy >90% for infrared reflectance data down to a wavelength averaged discriminant SNR>1. For Raman systems, we have demonstrated classification accuracies >90% for data with a peak discriminant SNR of approximately 6.

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Copyright © 2022 Society of Photo-Optical Instrumentation Engineers. This paper was presented at the SPIE Defense + Commercial Sensing, 4-7 April, 2022, Orlando, FL (Paper No. 12094-12), and is made available as an electronic reprint (preprint) with permission of SPIE. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

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