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Abstract: High resolution retinal imaging with a compact adaptive optics spectral domain optical coherence tomography system
Daniel X. Hammer, Nicusor V. Iftimia, Chad E. Bigelow, Teoman E. Ustun, Benjamin Bloom, R. Daniel Ferguson, Stephen A. Burns,
"High resolution retinal imaging with a compact adaptive optics spectral domain optical coherence tomography system
,"
presented at SPIE Photonics West BiOS 2007
(San Jose, CA)
,
(20 - 25 January2007).
Copyright © 2007 Society of Photo-Optical Instrumentation Engineers.
This paper was published in SPIE Photonics West BiOS 2007,
and is made available as an electronic reprint (preprint)
with permission of SPIE. One print or electronic copy may be made for personal use only. Systematic or multiple
reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this
paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Abstract
Adaptive optics (AO) is used to correct ocular aberrations primarily in the cornea, lens, and tear film of every eye.
Among other applications, AO allows high lateral resolution images to be acquired with scanning laser ophthalmoscopy(SLO) and optical coherence tomography (OCT). Spectral domain optical coherence tomography (SDOCT) is a highspeed imaging technique that can acquire cross-sectional scans with micron-scale axial resolution at tens to hundreds of kHz line rates. We present a compact clinical AO-SDOCT system that achieves micron-scale axial and lateral resolution of retinal structures. The system includes a line scanning laser ophthalmscope (LSLO) for simultaneous wide-field retinal viewing and selection of regions-of-interest. OCT and LSLO imaging and AO correction performance are characterized. We present a case study of a single subject with hyper-reflective lesions associated with stable, resolved central serous retinopathy to compare and contrast AO as applied to scanning laser ophthalmoscopy and optical coherence tomography. The two imaging modes are found to be complementary in terms of information on structure
morphology. Both provide additional information lacking in the other. This preliminary finding points to the power of
combining SLO and SDOCT in a single research instrument for exploration of disease mechanisms, retinal cellular
architecture, and visual psychophysics.
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