Physical Sciences Inc. Publications Abstract: Increased Signal and Resolution with Adaptive Optics Spectral Domain Optical Coherence Tomography

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Abstract: Increased Signal and Resolution with Adaptive Optics Spectral Domain Optical Coherence Tomography

Chad E. Bigelow, Nicusor V. Iftimia, R. Daniel Ferguson, Teoman E. Ustun, Benjamin Bloom, Daniel X. Hammer, "Increased Signal and Resolution with Adaptive Optics Spectral Domain Optical Coherence Tomography ," Journal of the Optical Society of America A: Advances in Retinal Imaging 24 (5) , 1327-1336 (May2007).

Reprinted by permission of the Optical Society of America. For permission to copy or republish, contact the Optical Society of America, 2010 Massachusetts Ave. NW, Washington, DC 20036-1023.

Abstract

We have developed a compact, multi-modal instrument for simultaneous acquisition of en-face quasi-confocal fundus images and adaptive optics (AO) spectral-domain optical coherence tomography (SDOCT) cross-sectional images. The optical system including all AO and SDOCT components occupies a 24×24 inch breadboard that can be readily transported for clinical applications. The AO component combines a Hartmann-Shack wavefront sensor and a MEMSbased deformable mirror to sense and correct ocular aberrations at 15 Hz with a maximum stroke of 4 µm. A broadband superluminescent diode source provides a theoretical 4-µm depth resolution for SDOCT imaging. The system has been tested on human volunteers and we observed up to 8-dB increase in reflectivity and a corresponding increase in lateral resolution as a result of AO correction.

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