Physical Sciences Inc. Publications Abstract: Noninvasive monitoring of blood composition

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Abstract: Noninvasive monitoring of blood composition

Nicusor V. Iftimia, Daniel X. Hammer, Dave I. Rosen, Chad E. Bigelow, R. Daniel Ferguson, "Noninvasive monitoring of blood composition ," presented at SPIE Photonics West (San Jose, CA) , (21-26 January2006).

This paper was published in SPIE Photonics West, and is made available as an electronic reprint (preprint) with permission of SPIE. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

Abstract

A novel instrument for real-time in vivo measurement of blood composition is presented. Two optical technologies are combined in this instrument: spectral domain low coherence interferometry (SD-LCI) and retinal tracking. Retinal tracking is used to stabilize the LCI beam on vessels. SD-LCI is used to get depth-reflectivity profiles within the vessels. Multiple signals are rapidly acquired, averaged and processed. Differences in the slopes of the depth reflectivity profiles for different subjects correspond to the difference in the scattering coefficient, which is proportional to the concentration of red blood cells per cubic mm of blood (hematocrit). Preliminary measurements on several healthy volunteers show a good correlation with the normal range of the hematocrit.

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