Physical Sciences Inc. Publications Abstract: Diode Laser Monitor for Singlet Molecular Oxygen

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Abstract: Diode Laser Monitor for Singlet Molecular Oxygen

S. Lee, L. Zhu, A. Minhaj, M.F. Hinds, A.A. Ferrante, D.H. Vu, D. Rosen, S.J. Davis, "Diode Laser Monitor for Singlet Molecular Oxygen ," presented at SPIE Photonics West (San Jose, CA) , (22 January - 7 February2005).

This paper was published in SPIE Photonics West, and is made available as an electronic reprint (preprint) with permission of SPIE. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

Abstract

Monitoring singlet molecular oxygen (¹O₂) produced by photodynamic therapy (PDT) can lead more precise and effective cancer treatment. Physical Sciences Inc. (PSI) has developed a singlet oxygen monitor based on a pulsed diode laser technology. In this paper, we present results of singlet oxygen detection in the solution phase and in a rat prostate cancer cell line, as well as PDT mechanism modeling. We describe an improved detection approach for singlet oxygen monitoring that employs a fiber-coupled optical set-up and fast data acquisition system.

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