Process Analytical Technology (PAT)

Monitor product quality by continuously measuring process parameters:

• Improve process understanding for better quality
• Increase throughput, reducing capital expenditures

Real-Time, On-Line Solvent Vapor Measurements

• Measured re-circulating solvent vapor concentration correlates with residual solvent in the solid product

(Tunable Diode Laser Absorption Spectroscopy, TDLAS)

PSI Field Proven Applications

• ✔ Fluidized bed dryers
• ✔ Fluidized bed spray coaters
• ✔ Fluidized bed granulators

Tunable Diode Laser Spectrometer

Solvent Drying Profiles

(* drying start times set to zero for comparison)

• Larger dry weight batch A takes longer to dry

(* drying start times set to zero for comparison)

William Kessler Physical Sciences Inc. 20 New England Business Center Andover, MA 01810-1077 Telephone: (978) 689-0003 Fax: (978) 689-3232 kessler@psicorp.com