PHARMACEUTICAL PROCESS ANALYTICAL TECHNOLOGY (PAT) SENSORS

PROCESS ANALYTICAL TECHNOLOGY (PAT)

• Improve process understanding for better quality
• Increase throughput, reducing capital expenditures

Real-Time, On-Line Solvent Vapor Measurements

• Measured re-circulating solvent vapor concentration correlates with residual solvent in the solid product

(Tunable Diode Laser Absorption Spectroscopy, TDLAS)

PSI Field Proven Applications

• ✔ Fluidized bed dryers
• ✔ Fluidized bed spray coaters
• ✔ Fluidized bed granulators

Tunable Diode Laser Spectrometer

Solvent Drying Profiles

(* drying start times set to zero for comparison)

• Larger dry weight batch A takes longer to dry

(* drying start times set to zero for comparison)

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