In Vivo Laryngeal Imaging Using Parallel OCT/Video Stroboscopy

Physical Sciences Inc. has been awarded a research program by the National Institutes of Health to develop a novel 3-D clinical imaging system combining parallel OCT and videostroboscopy into a cost-effective, common path transoral endoscope that will result in improved assessment of voice.

There is a constant need in the voice clinic to make effective diagnostic, surgical, and therapeutic decisions based on coupling visual judgments of vocal fold morphology and tissue motion with auditory perceptions of voice quality. Currently, laryngologists and speech-language pathologists do not have an endoscopic imaging tool that can directly capture the three-dimensional (3D) surface motion of the vocal folds in real time as patients phonate. To address this need, PSI, in collaboration with the Center for Laryngeal Surgery and Voice Rehabilitation at Massachusetts General Hospital, is developing a novel laryngeal imaging technique that combines swept-source optical coherence tomography with videostroboscopy to provide a 3D view of the vocal folds in real time during phonation, as well as tissue subsurface morphology. The novel optical coherence tomography (OCT) imaging approach, called parallel OCT (POCT), will be used to enable simultaneous interrogation of multiple locations along the vocal folds. This new imaging mode eliminates motion-blur artifacts exhibited by the sequential sampling provided by conventional flying-spot OCT.

During this effort, PSI will build a clinically viable transoral endoscope that will integrate POCT and video imaging. The POCT/videostroboscopy technique will be the first attempt to develop an ultra-fast diagnostic tool that performs superior-inferior surface and subsurface depth-sampling synchronized with the clinical standard of laryngeal videostroboscopy. This new technology will enable cost-effective management of patients to pinpoint problems affecting an individual’s vocal mechanism and to more optimally assess the efficacy of treatment before and after surgical intervention and/or voice therapy.

For more information, contact:

Dr. Nicusor Iftimia
Area Manager, Biomedical Optics Technology
Physical Sciences Inc.
Telephone: (978) 689-0003