Stabilized, Freeze Dried Bacteriophage for Use in Austere Environments

Physical Sciences Inc. (PSI), in collaboration with the University of Connecticut (UConn), has been awarded a research program from the US Army to develop a formulation and process for lyophilization, or freeze drying, of bacteriophages for improved stability to enable bacteriophage treatments in austere environments.

Effective management of military personnel that suffer wounds during multi-domain operations (MDO) requires care at the point of injury to prevent and treat infection to stabilize the wound. Due to increases in multidrug-resistant organisms, treatment modalities must include therapies outside of traditional antibiotics. Phage therapies consisting of cocktails of bacteriophages are a promising solution for treating infection, but poor stability outside of a highly controlled environment makes them inapplicable to austere environments typical encountered in MDO. Therefore, PSI’s technology will be capable of stabilizing bacteriophages for long-term storage at a wide range of environmental temperatures to enable reliable application of phage therapies in austere environments. This will lead to better outcomes for soldiers that suffer wounds during MDO.

For more information, contact:

William Kessler
Vice President, Applied Optics
Physical Sciences Inc.
Telephone: (978) 689-0003