RMS/mOCT Probe for Periodontal Health Status Assessment

PSI has been awarded a program by the National Institutes of Health, National Institute of Dental & Craniofacial Research, to develop a technology in periodontology to address the lack of tools to quantitatively and objectively assess the health/disease status of the gingival soft tissues.

Physical Sciences Inc. (PSI), in collaboration with The Forsyth Institute, Cambridge, MA, will combine high resolution micro-Optical Coherence Tomography (mOCT) with Raman microspectroscopy (RMS) for in vivo assessment of periodontal tissue integrity and therapy guidance. RMS and OCT are powerful optical technologies for investigating biological tissue health status. The combination of these technologies into an integrated hand-held probe will enable noninvasive and real-time screening and diagnosis of diseases around teeth (and dental implants) with high sensitivity and specificity. While OCT allows for the visualization of soft tissue anatomy, Raman is used to interrogate the biochemical composition of gingival tissues, as indicators of structural integrity. The complementary capabilities of these two optical technologies will be exploited to offer a clinically comprehensive set of parameters to more reliably and precisely determine the periodontal health status.

This innovative technology is of great clinical significance as it could provide clinicians with a novel diagnostic tool to detect early signs of periodontitis and accurately measure changes in intrinsic tissue properties to monitor disease activity in response to therapy. These will in turn allow for individualized therapeutic approaches for individuals at risk and poor responders to conventional therapy, with significant potential for improving prevention. This could significantly reduce healthcare costs by diagnosing these diseases at an earlier stage, when it is easier and less expensive to treat. Once validated for periodontal tissue, future applications may include the assessment of soft tissues around dental implants for early diagnosis of peri-implant diseases.

For more information, contact:

Dr. Nicusor Iftimia
Area Manager, Biomedical Optics Technology

iftimia@psicorp.com
Physical Sciences Inc.
Telephone: (978) 689-0003