Multimodal Otoendoscope for Non-invasive Diagnosis of Middle Ear Pathology

Under a research program from the National Institutes of Health, Physical Sciences Inc. (PSI), is developing a clinical otoendoscopic imaging system that combines PsOCT/RS with conventional video otoendoscopy,

This program addresses the growing clinical need for non-invasive diagnostic tools that can efficiently evaluate middle ear diseases. PSI, in collaboration with the Massachusetts Eye and Ear Infirmary (MEEI), are developing a clinically viable multimodal otoendoscopic imaging instrument that can analyze middle ear morphology, function, and biochemical changes in vivo in real-time. This will be possible by combining phase-sensitive optical coherence tomography (PsOCT) and Raman spectroscopy (RS) with a conventional video otoendoscopy (VO). Although this system can be applicable to various middle ear pathologies including otitis media, cholesteatoma, myringosclerosis and adenoma, in this phase we will focus on otitis media (OM), a complex infection and inflammatory disease with the highest prevalence in the middle ear.

Based on the results, a robust otoendoscopic system with improved performance and suitable size and design for clinical use in various middle ear pathologies will be developed.
This multimodal system will enable assessment of the morphological, biomechanical and biochemical characteristics of middle ear pathologies, and help clinicians to narrow the differential diagnosis of middle ear pathologies and formulate an adequate treatment plan for patients. PSI’s novel multimodal otoendoscopic system will contribute to an improved outcome for patient care and reduce healthcare costs.

For more information, contact:
Dr. Nicusor Iftimia
Area Manager, Biomedical Optics Technology
Physical Sciences Inc.
Telephone: (978) 689-0003