Multi-channel Functional Imaging Tool for Neuropsychological Drug Development

Physical Sciences Inc (PSI), in collaboration with Northeastern University, School of Pharmacy, has been awarded a research program by the National Institutes of Health (NIH) to develop a novel multimodal neuro-imaging tool to support the development of new drugs and therapies for neurological disorders.

PSI’s imaging tool is based on two-photon excitation microscopy (TPM) to measure fluorescence signals revealing drug delivery efficacy and its effect on the neuronal function. It will be capable of both real-time tracking of the drug distribution and monitoring the neural functions of individual neurons in the animal brain in vivo. The high throughput measurement provided by this technology will facilitate multiple tasks during neurological drug development including effective compound screening, drug delivery tracking, and efficacy testing. This versatile imaging tool will significantly reduce the cycle of Central Nervous System (CNS) drug development and testing, promoting less costly and more efficient clinical translation.

TPM is a widely used imaging technology in neuroscience research. However, existing research-orientated TPM systems are extremely expensive and complicated, and thus have very limited use in the pharmaceutical industry and biotechnology companies. This project aims to develop an affordable and easy-to-use TPM instrument to promote its translation of this enabling technology to pharmaceutical applications. The low cost and high portability will promote the wide-spread adoption of the technology within the pharmaceutical industry.

For more information, contact:

Dr. Nicusor Iftimia
Area Manager, Biomedical Optics Technology
iftimia@psicorp.com
Physical Sciences Inc.
Telephone: (978) 689-0003